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BDBM50316782 4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pentyl)-2,3,4,9-tetrahydro-1H-tetrahydrocarbazole-6-yloxy)ethyl)-phenol hydrochloride::CHEMBL1094825

SMILES: NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=MINFAHUQQXNXRH-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316782   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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Article
PubMed
n/an/a 5.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair