BDBM50317227 (E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(4-ethylpiperazin-1-yl)but-1-enyl)-6-methoxyquinoline-3-carbonitrile::CHEMBL1087978

SMILES: CCN1CCN(CC\C=C\c2cc3ncc(C#N)c(Nc4cc(OC)c(Cl)cc4Cl)c3cc2OC)CC1

InChI Key: InChIKey=YSOWEAROBZXTGU-FNORWQNLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50317227   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50317227 ((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(4-...) Show SMILES CCN1CCN(CC\C=C\c2cc3ncc(C#N)c(Nc4cc(OC)c(Cl)cc4Cl)c3cc2OC)CC1 Show InChI InChI=1S/C28H31Cl2N5O2/c1-4-34-9-11-35(12-10-34)8-6-5-7-19-13-24-21(14-26(19)36-2)28(20(17-31)18-32-24)33-25-16-27(37-3)23(30)15-22(25)29/h5,7,13-16,18H,4,6,8-12H2,1-3H3,(H,32,33)/b7-5+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay				Bioorg Med Chem Lett 20: 2924-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.025 BindingDB Entry DOI: 10.7270/Q2J38SR1
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50317227 ((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(4-...) Show SMILES CCN1CCN(CC\C=C\c2cc3ncc(C#N)c(Nc4cc(OC)c(Cl)cc4Cl)c3cc2OC)CC1 Show InChI InChI=1S/C28H31Cl2N5O2/c1-4-34-9-11-35(12-10-34)8-6-5-7-19-13-24-21(14-26(19)36-2)28(20(17-31)18-32-24)33-25-16-27(37-3)23(30)15-22(25)29/h5,7,13-16,18H,4,6,8-12H2,1-3H3,(H,32,33)/b7-5+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of human recombinant Src after 70 mins by FRET assay				Bioorg Med Chem Lett 20: 2924-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.025 BindingDB Entry DOI: 10.7270/Q2J38SR1
					More data for this Ligand-Target Pair