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BDBM50317583 1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-6-(2,4-difluorophenyl)-2H-quinolizin-2-one::CHEMBL1098546

SMILES: Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O

InChI Key: InChIKey=PKMRZFDBYNHTBY-UHFFFAOYSA-N

Data: 3 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50317583   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase p38


(Mus musculus (mouse))
BDBM50317583
PNG
(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)
Show SMILES Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(-7.52,-29.92,;-6.62,-31.17,;-5.08,-31.17,;-4.6,-32.63,;-5.84,-33.54,;-7.09,-32.63,;-5.85,-35.08,;-4.51,-35.86,;-4.51,-37.39,;-3.18,-38.17,;-5.85,-38.16,;-7.18,-37.4,;-8.51,-38.17,;-7.19,-35.86,;-5.85,-39.7,;-4.52,-40.48,;-3.2,-39.71,;-1.87,-40.47,;-1.87,-42.02,;-3.2,-42.78,;-3.2,-44.32,;-4.53,-45.09,;-4.54,-46.63,;-3.2,-47.4,;-3.2,-48.94,;-1.86,-46.62,;-1.87,-45.09,;-.54,-44.31,;-4.52,-42.02,;-5.85,-42.78,;-7.18,-42.02,;-7.18,-40.48,;-8.52,-39.71,)|
Show InChI InChI=1S/C24H13F4N3O2/c1-12-29-30-24(33-12)13-9-17(27)22(18(28)10-13)23-20-4-2-3-19(31(20)8-7-21(23)32)15-6-5-14(25)11-16(15)26/h2-11H,1H3
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n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse p38alpha after 3 hrs by SPA method


Bioorg Med Chem Lett 20: 2765-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.069
BindingDB Entry DOI: 10.7270/Q23T9HCC
More data for this
Ligand-Target Pair
Pregnane X receptor (PXR)


(Homo sapiens (Human))
BDBM50317583
PNG
(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)
Show SMILES Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(-7.52,-29.92,;-6.62,-31.17,;-5.08,-31.17,;-4.6,-32.63,;-5.84,-33.54,;-7.09,-32.63,;-5.85,-35.08,;-4.51,-35.86,;-4.51,-37.39,;-3.18,-38.17,;-5.85,-38.16,;-7.18,-37.4,;-8.51,-38.17,;-7.19,-35.86,;-5.85,-39.7,;-4.52,-40.48,;-3.2,-39.71,;-1.87,-40.47,;-1.87,-42.02,;-3.2,-42.78,;-3.2,-44.32,;-4.53,-45.09,;-4.54,-46.63,;-3.2,-47.4,;-3.2,-48.94,;-1.86,-46.62,;-1.87,-45.09,;-.54,-44.31,;-4.52,-42.02,;-5.85,-42.78,;-7.18,-42.02,;-7.18,-40.48,;-8.52,-39.71,)|
Show InChI InChI=1S/C24H13F4N3O2/c1-12-29-30-24(33-12)13-9-17(27)22(18(28)10-13)23-20-4-2-3-19(31(20)8-7-21(23)32)15-6-5-14(25)11-16(15)26/h2-11H,1H3
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n/an/an/an/a>3.00E+4n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of PXR


Bioorg Med Chem Lett 20: 2765-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.069
BindingDB Entry DOI: 10.7270/Q23T9HCC
More data for this
Ligand-Target Pair
Pregnane X receptor (PXR)


(Homo sapiens (Human))
BDBM50317583
PNG
(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)
Show SMILES Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(-7.52,-29.92,;-6.62,-31.17,;-5.08,-31.17,;-4.6,-32.63,;-5.84,-33.54,;-7.09,-32.63,;-5.85,-35.08,;-4.51,-35.86,;-4.51,-37.39,;-3.18,-38.17,;-5.85,-38.16,;-7.18,-37.4,;-8.51,-38.17,;-7.19,-35.86,;-5.85,-39.7,;-4.52,-40.48,;-3.2,-39.71,;-1.87,-40.47,;-1.87,-42.02,;-3.2,-42.78,;-3.2,-44.32,;-4.53,-45.09,;-4.54,-46.63,;-3.2,-47.4,;-3.2,-48.94,;-1.86,-46.62,;-1.87,-45.09,;-.54,-44.31,;-4.52,-42.02,;-5.85,-42.78,;-7.18,-42.02,;-7.18,-40.48,;-8.52,-39.71,)|
Show InChI InChI=1S/C24H13F4N3O2/c1-12-29-30-24(33-12)13-9-17(27)22(18(28)10-13)23-20-4-2-3-19(31(20)8-7-21(23)32)15-6-5-14(25)11-16(15)26/h2-11H,1H3
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n/an/an/an/a>3.00E+4n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of PXR


Bioorg Med Chem Lett 22: 5979-83 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.035
BindingDB Entry DOI: 10.7270/Q28P61S0
More data for this
Ligand-Target Pair
MAP kinase p38 beta


(Mus musculus (mouse))
BDBM50317583
PNG
(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)
Show SMILES Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(-7.52,-29.92,;-6.62,-31.17,;-5.08,-31.17,;-4.6,-32.63,;-5.84,-33.54,;-7.09,-32.63,;-5.85,-35.08,;-4.51,-35.86,;-4.51,-37.39,;-3.18,-38.17,;-5.85,-38.16,;-7.18,-37.4,;-8.51,-38.17,;-7.19,-35.86,;-5.85,-39.7,;-4.52,-40.48,;-3.2,-39.71,;-1.87,-40.47,;-1.87,-42.02,;-3.2,-42.78,;-3.2,-44.32,;-4.53,-45.09,;-4.54,-46.63,;-3.2,-47.4,;-3.2,-48.94,;-1.86,-46.62,;-1.87,-45.09,;-.54,-44.31,;-4.52,-42.02,;-5.85,-42.78,;-7.18,-42.02,;-7.18,-40.48,;-8.52,-39.71,)|
Show InChI InChI=1S/C24H13F4N3O2/c1-12-29-30-24(33-12)13-9-17(27)22(18(28)10-13)23-20-4-2-3-19(31(20)8-7-21(23)32)15-6-5-14(25)11-16(15)26/h2-11H,1H3
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay


Bioorg Med Chem Lett 22: 5979-83 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.035
BindingDB Entry DOI: 10.7270/Q28P61S0
More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50317583
PNG
(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)
Show SMILES Cc1nnc(o1)-c1cc(F)c(c(F)c1)-c1c2cccc(-c3ccc(F)cc3F)n2ccc1=O |(-7.52,-29.92,;-6.62,-31.17,;-5.08,-31.17,;-4.6,-32.63,;-5.84,-33.54,;-7.09,-32.63,;-5.85,-35.08,;-4.51,-35.86,;-4.51,-37.39,;-3.18,-38.17,;-5.85,-38.16,;-7.18,-37.4,;-8.51,-38.17,;-7.19,-35.86,;-5.85,-39.7,;-4.52,-40.48,;-3.2,-39.71,;-1.87,-40.47,;-1.87,-42.02,;-3.2,-42.78,;-3.2,-44.32,;-4.53,-45.09,;-4.54,-46.63,;-3.2,-47.4,;-3.2,-48.94,;-1.86,-46.62,;-1.87,-45.09,;-.54,-44.31,;-4.52,-42.02,;-5.85,-42.78,;-7.18,-42.02,;-7.18,-40.48,;-8.52,-39.71,)|
Show InChI InChI=1S/C24H13F4N3O2/c1-12-29-30-24(33-12)13-9-17(27)22(18(28)10-13)23-20-4-2-3-19(31(20)8-7-21(23)32)15-6-5-14(25)11-16(15)26/h2-11H,1H3
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PubMed
n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay


Bioorg Med Chem Lett 22: 5979-83 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.035
BindingDB Entry DOI: 10.7270/Q28P61S0
More data for this
Ligand-Target Pair