BDBM50317632 4-{2-(2-Carboxy-ethyl)-3-[6-(3-pyridin-4-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid::CHEMBL1099332
SMILES: OC(=O)CCCOc1cccc(CCCCCCOc2cc(cc(c2)-c2ccncc2)-c2ccsc2)c1CCC(O)=O
InChI Key: InChIKey=FBSYEMBBPSTFMK-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leukotriene B4 receptor (Homo sapiens (Human)) | BDBM50317632 (4-{2-(2-Carboxy-ethyl)-3-[6-(3-pyridin-4-yl-5-thio...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins | J Med Chem 53: 3502-16 (2010) Article DOI: 10.1021/jm1001919 BindingDB Entry DOI: 10.7270/Q2KW5G67 | |||||||||||
More data for this Ligand-Target Pair |