BDBM50318139 3-ethyl-1-(2-isopropoxyethyl)-5-(piperazin-1-yl)-N-(pyridin-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine::CHEMBL1098056

SMILES: CCc1nn(CCOC(C)C)c2c(Nc3ccccn3)nc(nc12)N1CCNCC1

InChI Key: InChIKey=NAESPHRIHJCLJZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318139   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50318139 (3-ethyl-1-(2-isopropoxyethyl)-5-(piperazin-1-yl)-N...) Show SMILES CCc1nn(CCOC(C)C)c2c(Nc3ccccn3)nc(nc12)N1CCNCC1 Show InChI InChI=1S/C21H30N8O/c1-4-16-18-19(29(27-16)13-14-30-15(2)3)20(24-17-7-5-6-8-23-17)26-21(25-18)28-11-9-22-10-12-28/h5-8,15,22H,4,9-14H2,1-3H3,(H,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.860	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 20: 3125-8 (2010) Article DOI: 10.1016/j.bmcl.2010.03.106 BindingDB Entry DOI: 10.7270/Q2WH2QXD
					More data for this Ligand-Target Pair