BDBM50318140 3-ethyl-5-(piperazin-1-yl)-N-(pyridin-2-yl)-1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine::CHEMBL1097717

SMILES: CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccccn3)nc(nc12)N1CCNCC1

InChI Key: InChIKey=IQSQJDZWCPHASP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50318140 (3-ethyl-5-(piperazin-1-yl)-N-(pyridin-2-yl)-1-(2-(...) Show SMILES CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccccn3)nc(nc12)N1CCNCC1 Show InChI InChI=1S/C20H25F3N8O/c1-2-14-16-17(31(29-14)11-12-32-13-20(21,22)23)18(26-15-5-3-4-6-25-15)28-19(27-16)30-9-7-24-8-10-30/h3-6,24H,2,7-13H2,1H3,(H,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 20: 3125-8 (2010) Article DOI: 10.1016/j.bmcl.2010.03.106 BindingDB Entry DOI: 10.7270/Q2WH2QXD
					More data for this Ligand-Target Pair