BDBM50318148 3-ethyl-N5-methyl-N5-(1-methylpiperidin-4-yl)-N7-(pyrimidin-4-yl)-1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-pyrazolo[4,3-d]pyrimidine-5,7-diamine::CHEMBL1098751

SMILES: CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(nc12)N(C)C1CCN(C)CC1

InChI Key: InChIKey=RFUQTPAAFXXWIY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318148   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50318148 (3-ethyl-N5-methyl-N5-(1-methylpiperidin-4-yl)-N7-(...) Show SMILES CCc1nn(CCOCC(F)(F)F)c2c(Nc3ccncn3)nc(nc12)N(C)C1CCN(C)CC1 Show InChI InChI=1S/C22H30F3N9O/c1-4-16-18-19(34(31-16)11-12-35-13-22(23,24)25)20(28-17-5-8-26-14-27-17)30-21(29-18)33(3)15-6-9-32(2)10-7-15/h5,8,14-15H,4,6-7,9-13H2,1-3H3,(H,26,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE5				Bioorg Med Chem Lett 20: 3125-8 (2010) Article DOI: 10.1016/j.bmcl.2010.03.106 BindingDB Entry DOI: 10.7270/Q2WH2QXD
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