BDBM50318160 8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one::CHEMBL1094483
SMILES: Cc1cc2CC(Cc2cc1C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12
InChI Key: InChIKey=PWAAGHQFYYZZAX-FQEVSTJZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50318160 (8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethylindan-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 522 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assay | J Med Chem 53: 3675-84 (2010) Article DOI: 10.1021/jm100068m BindingDB Entry DOI: 10.7270/Q27H1JRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (GUINEA PIG) | BDBM50318160 (8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethylindan-2-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response... | J Med Chem 53: 3675-84 (2010) Article DOI: 10.1021/jm100068m BindingDB Entry DOI: 10.7270/Q27H1JRT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50318160 (8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethylindan-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Agonist activity at human beta2 adrenergic receptor assessed as increase in cAMP level by whole cell assay | J Med Chem 53: 3675-84 (2010) Article DOI: 10.1021/jm100068m BindingDB Entry DOI: 10.7270/Q27H1JRT | |||||||||||
More data for this Ligand-Target Pair |