BDBM50318184 CHEMBL1095466::N-(3-bromophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

SMILES: Cc1ccccc1Cc1cc2c(Nc3cccc(Br)c3)ncnc2[nH]1

InChI Key: InChIKey=YBAKNSGHVALZHX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50318184   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50318184 (CHEMBL1095466 | N-(3-bromophenyl)-6-(2-methylbenzy...) Show SMILES Cc1ccccc1Cc1cc2c(Nc3cccc(Br)c3)ncnc2[nH]1 Show InChI InChI=1S/C20H17BrN4/c1-13-5-2-3-6-14(13)9-17-11-18-19(22-12-23-20(18)25-17)24-16-8-4-7-15(21)10-16/h2-8,10-12H,9H2,1H3,(H2,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISA				Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50318184 (CHEMBL1095466 | N-(3-bromophenyl)-6-(2-methylbenzy...) Show SMILES Cc1ccccc1Cc1cc2c(Nc3cccc(Br)c3)ncnc2[nH]1 Show InChI InChI=1S/C20H17BrN4/c1-13-5-2-3-6-14(13)9-17-11-18-19(22-12-23-20(18)25-17)24-16-8-4-7-15(21)10-16/h2-8,10-12H,9H2,1H3,(H2,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.82E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA				Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50318184 (CHEMBL1095466 | N-(3-bromophenyl)-6-(2-methylbenzy...) Show SMILES Cc1ccccc1Cc1cc2c(Nc3cccc(Br)c3)ncnc2[nH]1 Show InChI InChI=1S/C20H17BrN4/c1-13-5-2-3-6-14(13)9-17-11-18-19(22-12-23-20(18)25-17)24-16-8-4-7-15(21)10-16/h2-8,10-12H,9H2,1H3,(H2,22,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGFR1 phosphorylation in human A498 cells after 10 mins by FLISA				Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50318184 (CHEMBL1095466 | N-(3-bromophenyl)-6-(2-methylbenzy...) Show SMILES Cc1ccccc1Cc1cc2c(Nc3cccc(Br)c3)ncnc2[nH]1 Show InChI InChI=1S/C20H17BrN4/c1-13-5-2-3-6-14(13)9-17-11-18-19(22-12-23-20(18)25-17)24-16-8-4-7-15(21)10-16/h2-8,10-12H,9H2,1H3,(H2,22,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISA				Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB
					More data for this Ligand-Target Pair