BDBM50318187 6-(2,4-dichlorobenzyl)-N-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::CHEMBL1094784
SMILES: FC(F)(F)c1cccc(Nc2ncnc3[nH]c(Cc4ccc(Cl)cc4Cl)cc23)c1
InChI Key: InChIKey=KREFSQWWLAZRAY-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50318187 (6-(2,4-dichlorobenzyl)-N-(3-(trifluoromethyl)pheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISA | Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50318187 (6-(2,4-dichlorobenzyl)-N-(3-(trifluoromethyl)pheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA | Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human)) | BDBM50318187 (6-(2,4-dichlorobenzyl)-N-(3-(trifluoromethyl)pheny...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of VEGFR1 phosphorylation in human A498 cells after 10 mins by FLISA | Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50318187 (6-(2,4-dichlorobenzyl)-N-(3-(trifluoromethyl)pheny...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISA | Bioorg Med Chem 18: 3575-87 (2010) Article DOI: 10.1016/j.bmc.2010.03.052 BindingDB Entry DOI: 10.7270/Q2V69JRB | |||||||||||
More data for this Ligand-Target Pair |