null
SMILES: Fc1ccc(C#N)c(O\N=C2/CCCC(=C2)C#Cc2ccccn2)c1
InChI Key: InChIKey=LVUPOZOBRTWBQM-LYBHJNIJSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50318378 ((E)-2-fluoro-4-(3-(pyridin-2-ylethynyl)cyclohex-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 73.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ETH Zurich Curated by ChEMBL | Assay Description Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting | J Med Chem 53: 4009-17 (2010) Article DOI: 10.1021/jm901850k BindingDB Entry DOI: 10.7270/Q2T72HMH | |||||||||||
More data for this Ligand-Target Pair |