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SMILES: Fc1cc(O\N=C2/CCCC(=C2)C#Cc2ccccn2)ccc1C#N

InChI Key: InChIKey=LJRJQJYXJJSYID-HKOYGPOVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318379   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50318379
PNG
((E)-4-fluoro-2-(3-(pyridin-2-ylethynyl)cyclohex-2-...)
Show SMILES Fc1cc(O\N=C2/CCCC(=C2)C#Cc2ccccn2)ccc1C#N |c:10|
Show InChI InChI=1S/C20H14FN3O/c21-20-13-19(10-8-16(20)14-22)25-24-18-6-3-4-15(12-18)7-9-17-5-1-2-11-23-17/h1-2,5,8,10-13H,3-4,6H2/b24-18+
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Article
PubMed
 56.1n/an/an/an/an/an/an/an/a



ETH Zurich

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting

J Med Chem 53: 4009-17 (2010)


Article DOI: 10.1021/jm901850k
BindingDB Entry DOI: 10.7270/Q2T72HMH
More data for this
Ligand-Target Pair