BindingDB PrimarySearch

BDBM50318567 2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano-[4,3-d]pyrimidin-4-ol::2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol::CHEMBL1086580

SMILES: FC(F)(F)c1ccc(cc1)-c1nc2CCSCc2c(=O)[nH]1

InChI Key: InChIKey=KLGQSVMIPOVQAX-UHFFFAOYSA-N

Data: 38 IC50 5 Kd 1 EC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50318567
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of human tankyrase2 after 2 hrs by spectrophotometry				ACS Med Chem Lett 4: 1173-7 (2013) Article DOI: 10.1021/ml400260b BindingDB Entry DOI: 10.7270/Q2XG9SKC
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abo Akademi University Curated by ChEMBL					Assay Description Inhibition of TNKS2				J Med Chem 55: 1360-7 (2012) Article DOI: 10.1021/jm201510p BindingDB Entry DOI: 10.7270/Q2WS8V8K
Abo Akademi University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of human recombinant IMPDH2 by spectrophotometry				ACS Med Chem Lett 4: 1173-7 (2013) Article DOI: 10.1021/ml400260b BindingDB Entry DOI: 10.7270/Q2XG9SKC
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of PARP1 (unknown origin)				ACS Med Chem Lett 4: 1173-7 (2013) Article DOI: 10.1021/ml400260b BindingDB Entry DOI: 10.7270/Q2XG9SKC
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of tankyrase2 (unknown origin)				ACS Med Chem Lett 4: 1173-7 (2013) Article DOI: 10.1021/ml400260b BindingDB Entry DOI: 10.7270/Q2XG9SKC
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of tankyrase1 (unknown origin)				ACS Med Chem Lett 4: 1173-7 (2013) Article DOI: 10.1021/ml400260b BindingDB Entry DOI: 10.7270/Q2XG9SKC
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of TNKS-1 (unknown origin) by TCF/beta-catenin-dependent reporter assay				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of TNKS-2 (unknown origin) by TCF/beta-catenin-dependent reporter assay				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of human TNKS2 catalytic activity				Bioorg Med Chem 23: 3013-32 (2015) Article DOI: 10.1016/j.bmc.2015.05.005 BindingDB Entry DOI: 10.7270/Q2X35072
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of human TNKS1 catalytic activity				Bioorg Med Chem 23: 3013-32 (2015) Article DOI: 10.1016/j.bmc.2015.05.005 BindingDB Entry DOI: 10.7270/Q2X35072
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of PARP1 (unknown origin) after 1 hr by spectrophotometry				ACS Med Chem Lett 4: 1173-7 (2013) Article DOI: 10.1021/ml400260b BindingDB Entry DOI: 10.7270/Q2XG9SKC
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Wnt-3a (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolin				J Med Chem 56: 6495-511 (2013) Article DOI: 10.1021/jm400807n BindingDB Entry DOI: 10.7270/Q24Q7WFB
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PARP2 (unknown origin) assessed as nicotinamide concentration by LC-MS analysis				J Med Chem 56: 6495-511 (2013) Article DOI: 10.1021/jm400807n BindingDB Entry DOI: 10.7270/Q24Q7WFB
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PARP1 (unknown origin) assessed as nicotinamide concentration by LC-MS analysis				J Med Chem 56: 6495-511 (2013) Article DOI: 10.1021/jm400807n BindingDB Entry DOI: 10.7270/Q24Q7WFB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Incorporated Curated by ChEMBL					Assay Description Inhibition of PARP2 (unknown origin) after 60 mins by LC-MS analysis				J Med Chem 56: 7049-59 (2013) Article DOI: 10.1021/jm400826j BindingDB Entry DOI: 10.7270/Q2KS6SZ5
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Incorporated Curated by ChEMBL					Assay Description Inhibition of human PARP1 after 60 mins by LC-MS analysis				J Med Chem 56: 7049-59 (2013) Article DOI: 10.1021/jm400826j BindingDB Entry DOI: 10.7270/Q2KS6SZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 6 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanyang Technological University Curated by ChEMBL					Assay Description Inhibition of PARP6 (unknown origin)				J Med Chem 56: 4497-508 (2013) Article DOI: 10.1021/jm400211f BindingDB Entry DOI: 10.7270/Q23R0V82
Nanyang Technological University Curated by ChEMBL					More data for this Ligand-Target Pair
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3) (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanyang Technological University Curated by ChEMBL					Assay Description Inhibition of PARP3 (unknown origin)				J Med Chem 56: 4497-508 (2013) Article DOI: 10.1021/jm400211f BindingDB Entry DOI: 10.7270/Q23R0V82
Nanyang Technological University Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Nanyang Technological University Curated by ChEMBL					Assay Description Inhibition of PARP2 (unknown origin)				J Med Chem 56: 4497-508 (2013) Article DOI: 10.1021/jm400211f BindingDB Entry DOI: 10.7270/Q23R0V82
Nanyang Technological University Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Nanyang Technological University Curated by ChEMBL					Assay Description Inhibition of PARP1 (unknown origin)				J Med Chem 56: 4497-508 (2013) Article DOI: 10.1021/jm400211f BindingDB Entry DOI: 10.7270/Q23R0V82
Nanyang Technological University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PARP1 (unknown origin)				J Med Chem 56: 1341-5 (2013) Article DOI: 10.1021/jm301607v BindingDB Entry DOI: 10.7270/Q21N82DQ
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PARP2 (unknown origin)				J Med Chem 56: 1341-5 (2013) Article DOI: 10.1021/jm301607v BindingDB Entry DOI: 10.7270/Q21N82DQ
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human TNKS2 (946 to 1162 amino acid residues) after 60 mins by autoparsylation assay				J Med Chem 56: 1341-5 (2013) Article DOI: 10.1021/jm301607v BindingDB Entry DOI: 10.7270/Q21N82DQ
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human TNKS1 (1091 to 1325 amino acid residues) after 60 mins by autoparsylation assay				J Med Chem 56: 1341-5 (2013) Article DOI: 10.1021/jm301607v BindingDB Entry DOI: 10.7270/Q21N82DQ
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PARP1 autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysis				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of PARP2 autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysis				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human ERG by radioligand binding assay				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair
Axin-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	371	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISA				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged TNKS1P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysis				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of GST-tagged TNKS2P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysis				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Wnt-3a (Mus musculus)	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of CYP2C9				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of CYP3A4				J Med Chem 55: 1127-36 (2012) Article DOI: 10.1021/jm2011222 BindingDB Entry DOI: 10.7270/Q2BK1DCV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Karolinska Institutet Curated by ChEMBL					Assay Description Inhibition of TNKS2				J Med Chem 53: 5352-5 (2010) Article DOI: 10.1021/jm100249w BindingDB Entry DOI: 10.7270/Q2M32WQ5
Karolinska Institutet Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Karolinska Institutet Curated by ChEMBL					Assay Description Inhibition of TNKS1				J Med Chem 53: 5352-5 (2010) Article DOI: 10.1021/jm100249w BindingDB Entry DOI: 10.7270/Q2M32WQ5
Karolinska Institutet Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
Karolinska Institutet Curated by ChEMBL					Assay Description Binding affinity to TNKS2				J Med Chem 53: 5352-5 (2010) Article DOI: 10.1021/jm100249w BindingDB Entry DOI: 10.7270/Q2M32WQ5
Karolinska Institutet Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Karolinska Institutet Curated by ChEMBL					Assay Description Binding affinity to TNKS1				J Med Chem 53: 5352-5 (2010) Article DOI: 10.1021/jm100249w BindingDB Entry DOI: 10.7270/Q2M32WQ5
Karolinska Institutet Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
Karolinska Institutet Curated by ChEMBL					Assay Description Binding affinity to full-length human recombinant TNSK2 expressed in Escherichia coli by isothermal titration calorimetry				J Med Chem 53: 5352-5 (2010) Article DOI: 10.1021/jm100249w BindingDB Entry DOI: 10.7270/Q2M32WQ5
Karolinska Institutet Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a
Karolinska Institutet Curated by ChEMBL					Assay Description Binding affinity to human recombinant TNSK1 expressed in Escherichia coli by isothermal titration calorimetry				J Med Chem 53: 5352-5 (2010) Article DOI: 10.1021/jm100249w BindingDB Entry DOI: 10.7270/Q2M32WQ5
Karolinska Institutet Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a
Karolinska Institutet Curated by ChEMBL					Assay Description Binding affinity to PARP1 by isothermal titration calorimetry				J Med Chem 53: 5352-5 (2010) Article DOI: 10.1021/jm100249w BindingDB Entry DOI: 10.7270/Q2M32WQ5
Karolinska Institutet Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abo Akademi University Curated by ChEMBL					Assay Description Inhibition of PARP1				J Med Chem 55: 1360-7 (2012) Article DOI: 10.1021/jm201510p BindingDB Entry DOI: 10.7270/Q2WS8V8K
Abo Akademi University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Abo Akademi University Curated by ChEMBL					Assay Description Inhibition of PARP2				J Med Chem 55: 1360-7 (2012) Article DOI: 10.1021/jm201510p BindingDB Entry DOI: 10.7270/Q2WS8V8K
Abo Akademi University Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Abo Akademi University Curated by ChEMBL					Assay Description Inhibition of TNKS1				J Med Chem 55: 1360-7 (2012) Article DOI: 10.1021/jm201510p BindingDB Entry DOI: 10.7270/Q2WS8V8K
Abo Akademi University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by ChEMBL					Assay Description Inhibition of human tankyrase1 after 30 mins by spectrophotometry				ACS Med Chem Lett 4: 1173-7 (2013) Article DOI: 10.1021/ml400260b BindingDB Entry DOI: 10.7270/Q2XG9SKC
University of Bath Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)