BDBM50318570 2-{4-[6-Bromo-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]-pyridin-7-yl]-piperazin-1-yl}-N-thiazol-2-yl-acetamide::CHEMBL1086309

SMILES: CN(C)c1ccc(cc1)-c1nc2ncc(Br)c(N3CCN(CC(=O)Nc4nccs4)CC3)c2[nH]1

InChI Key: InChIKey=CPMOSBBQHLDNNM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50318570   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50318570 (2-{4-[6-Bromo-2-(4-dimethylaminophenyl)-3H-imidazo...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ncc(Br)c(N3CCN(CC(=O)Nc4nccs4)CC3)c2[nH]1 Show InChI InChI=1S/C23H25BrN8OS/c1-30(2)16-5-3-15(4-6-16)21-28-19-20(17(24)13-26-22(19)29-21)32-10-8-31(9-11-32)14-18(33)27-23-25-7-12-34-23/h3-7,12-13H,8-11,14H2,1-2H3,(H,25,27,33)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of human recombinant Aurora A expressed in baculovirus system				J Med Chem 53: 5213-28 (2010) Article DOI: 10.1021/jm100262j BindingDB Entry DOI: 10.7270/Q2GB251P
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50318570 (2-{4-[6-Bromo-2-(4-dimethylaminophenyl)-3H-imidazo...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ncc(Br)c(N3CCN(CC(=O)Nc4nccs4)CC3)c2[nH]1 Show InChI InChI=1S/C23H25BrN8OS/c1-30(2)16-5-3-15(4-6-16)21-28-19-20(17(24)13-26-22(19)29-21)32-10-8-31(9-11-32)14-18(33)27-23-25-7-12-34-23/h3-7,12-13H,8-11,14H2,1-2H3,(H,25,27,33)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of Aurora A				Eur J Med Chem 46: 77-94 (2010) Article DOI: 10.1016/j.ejmech.2010.10.017 BindingDB Entry DOI: 10.7270/Q25X296N
					More data for this Ligand-Target Pair