BDBM50318573 2-[4-(6-Bromo-2-phenyl-3H-imidazo[4,5-b]pyridin-7-yl)-piperazin-1-yl]-Nthiazol-2-yl-acetamide::CHEMBL1082830

SMILES: Brc1cnc2nc([nH]c2c1N1CCN(CC(=O)Nc2nccs2)CC1)-c1ccccc1

InChI Key: InChIKey=CVZQTKSFZPNWGS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50318573   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50318573 (2-[4-(6-Bromo-2-phenyl-3H-imidazo[4,5-b]pyridin-7-...) Show SMILES Brc1cnc2nc([nH]c2c1N1CCN(CC(=O)Nc2nccs2)CC1)-c1ccccc1 Show InChI InChI=1S/C21H20BrN7OS/c22-15-12-24-20-17(26-19(27-20)14-4-2-1-3-5-14)18(15)29-9-7-28(8-10-29)13-16(30)25-21-23-6-11-31-21/h1-6,11-12H,7-10,13H2,(H,23,25,30)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of human recombinant Aurora A expressed in baculovirus system				J Med Chem 53: 5213-28 (2010) Article DOI: 10.1021/jm100262j BindingDB Entry DOI: 10.7270/Q2GB251P
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50318573 (2-[4-(6-Bromo-2-phenyl-3H-imidazo[4,5-b]pyridin-7-...) Show SMILES Brc1cnc2nc([nH]c2c1N1CCN(CC(=O)Nc2nccs2)CC1)-c1ccccc1 Show InChI InChI=1S/C21H20BrN7OS/c22-15-12-24-20-17(26-19(27-20)14-4-2-1-3-5-14)18(15)29-9-7-28(8-10-29)13-16(30)25-21-23-6-11-31-21/h1-6,11-12H,7-10,13H2,(H,23,25,30)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of Aurora A				Eur J Med Chem 46: 77-94 (2010) Article DOI: 10.1016/j.ejmech.2010.10.017 BindingDB Entry DOI: 10.7270/Q25X296N
					More data for this Ligand-Target Pair