BDBM50318587 6-Bromo-2-(4-methoxyphenyl)-7-(4-(pyridin-3-ylmethyl)piperazin-1-yl)-3Himidazo[4,5-b]pyridine::CHEMBL1083801

SMILES: COc1ccc(cc1)-c1nc2ncc(Br)c(N3CCN(Cc4cccnc4)CC3)c2[nH]1

InChI Key: InChIKey=DDKFQQFHOJBBBE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50318587   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50318587 (6-Bromo-2-(4-methoxyphenyl)-7-(4-(pyridin-3-ylmeth...) Show SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(N3CCN(Cc4cccnc4)CC3)c2[nH]1 Show InChI InChI=1S/C23H23BrN6O/c1-31-18-6-4-17(5-7-18)22-27-20-21(19(24)14-26-23(20)28-22)30-11-9-29(10-12-30)15-16-3-2-8-25-13-16/h2-8,13-14H,9-12,15H2,1H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of human recombinant Aurora A expressed in baculovirus system				J Med Chem 53: 5213-28 (2010) Article DOI: 10.1021/jm100262j BindingDB Entry DOI: 10.7270/Q2GB251P
					More data for this Ligand-Target Pair