BDBM50319168 1-Cyclohexyl-3,4-dimethyl-8-methoxy-imidazo[1,5-a]pyrido[3,2-e]pyrazine::CHEMBL1085405

SMILES: COc1ccc2nc(C)c3c(C)nc(C4CCCCC4)n3c2n1

InChI Key: InChIKey=GGLOHDIXAIIIHN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50319168   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50319168 (1-Cyclohexyl-3,4-dimethyl-8-methoxy-imidazo[1,5-a]...) Show SMILES COc1ccc2nc(C)c3c(C)nc(C4CCCCC4)n3c2n1 Show InChI InChI=1S/C18H22N4O/c1-11-16-12(2)20-17(13-7-5-4-6-8-13)22(16)18-14(19-11)9-10-15(21-18)23-3/h9-10,13H,4-8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Biotie Therapies GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...				J Med Chem 53: 4399-411 (2010) Article DOI: 10.1021/jm1002793 BindingDB Entry DOI: 10.7270/Q2MK6D3N
					More data for this Ligand-Target Pair