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BDBM50319277 5-fluoro-4-methyl-2-(2-methyl-4-(3-(4-methylpiperazin-1-yl)propoxy)phenyl)-1H-benzo[d]imidazole::CHEMBL1086460

SMILES: CN1CCN(CCCOc2ccc(-c3nc4ccc(F)c(C)c4[nH]3)c(C)c2)CC1

InChI Key: InChIKey=JVUHNEKBJYRDTQ-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50319277   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319277
PNG
(5-fluoro-4-methyl-2-(2-methyl-4-(3-(4-methylpipera...)
Show SMILES CN1CCN(CCCOc2ccc(-c3nc4ccc(F)c(C)c4[nH]3)c(C)c2)CC1
Show InChI InChI=1S/C23H29FN4O/c1-16-15-18(29-14-4-9-28-12-10-27(3)11-13-28)5-6-19(16)23-25-21-8-7-20(24)17(2)22(21)26-23/h5-8,15H,4,9-14H2,1-3H3,(H,25,26)
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KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
32n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319277
PNG
(5-fluoro-4-methyl-2-(2-methyl-4-(3-(4-methylpipera...)
Show SMILES CN1CCN(CCCOc2ccc(-c3nc4ccc(F)c(C)c4[nH]3)c(C)c2)CC1
Show InChI InChI=1S/C23H29FN4O/c1-16-15-18(29-14-4-9-28-12-10-27(3)11-13-28)5-6-19(16)23-25-21-8-7-20(24)17(2)22(21)26-23/h5-8,15H,4,9-14H2,1-3H3,(H,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 50n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair