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BDBM50319287 (+/-)-5-fluoro-2-(4-(3-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)propoxy)-2-methylphenyl)-4-methyl-1H-benzo[d]imidazole::CHEMBL1083098

SMILES: Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2ccc(F)c(C)c2[nH]1

InChI Key: InChIKey=GWXYGVYIVWODLJ-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50319287   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319287
PNG
((+/-)-5-fluoro-2-(4-(3-(hexahydropyrrolo[3,4-b]pyr...)
Show SMILES Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C24H29FN4O/c1-15-12-18(30-11-3-10-29-13-17-8-9-26-22(17)14-29)4-5-19(15)24-27-21-7-6-20(25)16(2)23(21)28-24/h4-7,12,17,22,26H,3,8-11,13-14H2,1-2H3,(H,27,28)
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UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
26n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319287
PNG
((+/-)-5-fluoro-2-(4-(3-(hexahydropyrrolo[3,4-b]pyr...)
Show SMILES Cc1cc(OCCCN2CC3CCNC3C2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C24H29FN4O/c1-15-12-18(30-11-3-10-29-13-17-8-9-26-22(17)14-29)4-5-19(15)24-27-21-7-6-20(25)16(2)23(21)28-24/h4-7,12,17,22,26H,3,8-11,13-14H2,1-2H3,(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair