BDBM50319294 (+/-)-5-fluoro-4-methyl-2-(2-methyl-4-(3-(3-methyl-3,6-diazabicyclo[3.1.0]hexan-6-yl)propoxy)phenyl)-1H-benzo[d]imidazole::CHEMBL1086085

SMILES: CN1CC2C(C1)N2CCCOc1ccc(-c2nc3ccc(F)c(C)c3[nH]2)c(C)c1

InChI Key: InChIKey=VVCHINSCYNDMKE-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50319294   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50319294 ((+/-)-5-fluoro-4-methyl-2-(2-methyl-4-(3-(3-methyl...) Show SMILES CN1CC2C(C1)N2CCCOc1ccc(-c2nc3ccc(F)c(C)c3[nH]2)c(C)c1 Show InChI InChI=1S/C23H27FN4O/c1-14-11-16(29-10-4-9-28-20-12-27(3)13-21(20)28)5-6-17(14)23-25-19-8-7-18(24)15(2)22(19)26-23/h5-8,11,20-21H,4,9-10,12-13H2,1-3H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	77	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor				Bioorg Med Chem Lett 20: 3367-71 (2010) Article DOI: 10.1016/j.bmcl.2010.04.017 BindingDB Entry DOI: 10.7270/Q23J3D4Z
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50319294 ((+/-)-5-fluoro-4-methyl-2-(2-methyl-4-(3-(3-methyl...) Show SMILES CN1CC2C(C1)N2CCCOc1ccc(-c2nc3ccc(F)c(C)c3[nH]2)c(C)c1 Show InChI InChI=1S/C23H27FN4O/c1-14-11-16(29-10-4-9-28-20-12-27(3)13-21(20)28)5-6-17(14)23-25-19-8-7-18(24)15(2)22(19)26-23/h5-8,11,20-21H,4,9-10,12-13H2,1-3H3,(H,25,26)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	710	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...				Bioorg Med Chem Lett 20: 3367-71 (2010) Article DOI: 10.1016/j.bmcl.2010.04.017 BindingDB Entry DOI: 10.7270/Q23J3D4Z
					More data for this Ligand-Target Pair