BDBM50319569 1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)urea::CHEMBL1084633

SMILES: CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)NC(C)(C)C)c2ccccc12

InChI Key: InChIKey=OKKAENUKIYEBBD-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50319569   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM50319569 (1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)NC(C)(C)C)c2ccccc12 Show InChI InChI=1S/C25H26N6O2/c1-25(2,3)31-24(32)30-19-11-12-21(17-9-6-5-8-16(17)19)33-22-18(10-7-14-27-22)20-13-15-28-23(26-4)29-20/h5-15H,1-4H3,(H,26,28,29)(H2,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora B				J Med Chem 53: 4502-10 (2010) Article DOI: 10.1021/jm100301x BindingDB Entry DOI: 10.7270/Q2T43T83
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50319569 (1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)NC(C)(C)C)c2ccccc12 Show InChI InChI=1S/C25H26N6O2/c1-25(2,3)31-24(32)30-19-11-12-21(17-9-6-5-8-16(17)19)33-22-18(10-7-14-27-22)20-13-15-28-23(26-4)29-20/h5-15H,1-4H3,(H,26,28,29)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Aurora A				J Med Chem 53: 4502-10 (2010) Article DOI: 10.1021/jm100301x BindingDB Entry DOI: 10.7270/Q2T43T83
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50319569 (1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)NC(C)(C)C)c2ccccc12 Show InChI InChI=1S/C25H26N6O2/c1-25(2,3)31-24(32)30-19-11-12-21(17-9-6-5-8-16(17)19)33-22-18(10-7-14-27-22)20-13-15-28-23(26-4)29-20/h5-15H,1-4H3,(H,26,28,29)(H2,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	215	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2				J Med Chem 53: 4502-10 (2010) Article DOI: 10.1021/jm100301x BindingDB Entry DOI: 10.7270/Q2T43T83
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50319569 (1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)NC(C)(C)C)c2ccccc12 Show InChI InChI=1S/C25H26N6O2/c1-25(2,3)31-24(32)30-19-11-12-21(17-9-6-5-8-16(17)19)33-22-18(10-7-14-27-22)20-13-15-28-23(26-4)29-20/h5-15H,1-4H3,(H,26,28,29)(H2,30,31,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of LCK				J Med Chem 53: 4502-10 (2010) Article DOI: 10.1021/jm100301x BindingDB Entry DOI: 10.7270/Q2T43T83
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50319569 (1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)NC(C)(C)C)c2ccccc12 Show InChI InChI=1S/C25H26N6O2/c1-25(2,3)31-24(32)30-19-11-12-21(17-9-6-5-8-16(17)19)33-22-18(10-7-14-27-22)20-13-15-28-23(26-4)29-20/h5-15H,1-4H3,(H,26,28,29)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of KDR				J Med Chem 53: 4502-10 (2010) Article DOI: 10.1021/jm100301x BindingDB Entry DOI: 10.7270/Q2T43T83
					More data for this Ligand-Target Pair