BDBM50319632 CHEMBL1084890::N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-phenylacetamide

SMILES: Clc1cc2c(cc[nH]c2=O)cc1NC(=O)Cc1ccccc1

InChI Key: InChIKey=NUMKSHPDXMTIAA-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50319632   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Myotonin-protein kinase (Homo sapiens (Human))	BDBM50319632 (CHEMBL1084890 | N-(7-chloro-1-oxo-1,2-dihydroisoqu...) Show SMILES Clc1cc2c(cc[nH]c2=O)cc1NC(=O)Cc1ccccc1 Show InChI InChI=1S/C17H13ClN2O2/c18-14-10-13-12(6-7-19-17(13)22)9-15(14)20-16(21)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H,19,22)(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of DMPK				Bioorg Med Chem Lett 20: 3235-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.070 BindingDB Entry DOI: 10.7270/Q21N819Z
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50319632 (CHEMBL1084890 | N-(7-chloro-1-oxo-1,2-dihydroisoqu...) Show SMILES Clc1cc2c(cc[nH]c2=O)cc1NC(=O)Cc1ccccc1 Show InChI InChI=1S/C17H13ClN2O2/c18-14-10-13-12(6-7-19-17(13)22)9-15(14)20-16(21)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H,19,22)(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of ROCK2				Bioorg Med Chem Lett 20: 3235-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.070 BindingDB Entry DOI: 10.7270/Q21N819Z
					More data for this Ligand-Target Pair
Protein kinase N2 (Homo sapiens (Human))	BDBM50319632 (CHEMBL1084890 | N-(7-chloro-1-oxo-1,2-dihydroisoqu...) Show SMILES Clc1cc2c(cc[nH]c2=O)cc1NC(=O)Cc1ccccc1 Show InChI InChI=1S/C17H13ClN2O2/c18-14-10-13-12(6-7-19-17(13)22)9-15(14)20-16(21)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H,19,22)(H,20,21)	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Prkcl2				Bioorg Med Chem Lett 20: 3235-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.070 BindingDB Entry DOI: 10.7270/Q21N819Z
					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50319632 (CHEMBL1084890 | N-(7-chloro-1-oxo-1,2-dihydroisoqu...) Show SMILES Clc1cc2c(cc[nH]c2=O)cc1NC(=O)Cc1ccccc1 Show InChI InChI=1S/C17H13ClN2O2/c18-14-10-13-12(6-7-19-17(13)22)9-15(14)20-16(21)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H,19,22)(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Prkce				Bioorg Med Chem Lett 20: 3235-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.070 BindingDB Entry DOI: 10.7270/Q21N819Z
					More data for this Ligand-Target Pair
Cell division control protein 42 homolog (Homo sapiens (Human))	BDBM50319632 (CHEMBL1084890 | N-(7-chloro-1-oxo-1,2-dihydroisoqu...) Show SMILES Clc1cc2c(cc[nH]c2=O)cc1NC(=O)Cc1ccccc1 Show InChI InChI=1S/C17H13ClN2O2/c18-14-10-13-12(6-7-19-17(13)22)9-15(14)20-16(21)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H,19,22)(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of CDc42				Bioorg Med Chem Lett 20: 3235-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.070 BindingDB Entry DOI: 10.7270/Q21N819Z
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50319632 (CHEMBL1084890 | N-(7-chloro-1-oxo-1,2-dihydroisoqu...) Show SMILES Clc1cc2c(cc[nH]c2=O)cc1NC(=O)Cc1ccccc1 Show InChI InChI=1S/C17H13ClN2O2/c18-14-10-13-12(6-7-19-17(13)22)9-15(14)20-16(21)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H,19,22)(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of ROCK1				Bioorg Med Chem Lett 20: 3235-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.070 BindingDB Entry DOI: 10.7270/Q21N819Z
					More data for this Ligand-Target Pair