BDBM50319661 (R)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one::CHEMBL1085105::CHEMBL1085839
SMILES: CC(C)c1sc(N[C@@H]2C[C@H]3CC[C@@H]2C3)nc1O
InChI Key: InChIKey=KUEKSTOVOGPIFY-IVZWLZJFSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50319661 ((R)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 227 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assay | J Med Chem 53: 4481-7 (2010) Article DOI: 10.1021/jm100242d BindingDB Entry DOI: 10.7270/Q2WW7HVQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50319661 ((R)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 770 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-cortisone human 17beta-HSD1 expressed in Escherichia coli after 30 mins by scintillation proximity assay | J Med Chem 53: 4481-7 (2010) Article DOI: 10.1021/jm100242d BindingDB Entry DOI: 10.7270/Q2WW7HVQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50319661 ((R)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 931 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assay | J Med Chem 53: 4481-7 (2010) Article DOI: 10.1021/jm100242d BindingDB Entry DOI: 10.7270/Q2WW7HVQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human)) | BDBM50319661 ((R)-2-((1R,2R,4S)-Bicyclo[2.2.1]heptan-2-ylamino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-cortisone human 17beta-HSD1 expressed in HEK293 cells after 30 mins by scintillation proximity assay | J Med Chem 53: 4481-7 (2010) Article DOI: 10.1021/jm100242d BindingDB Entry DOI: 10.7270/Q2WW7HVQ | |||||||||||
More data for this Ligand-Target Pair |