BDBM50319838 (S)-4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxamido)ethyl)benzoic acid::CHEMBL1083400
SMILES: C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3ccc(cc3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O
InChI Key: InChIKey=GRRCVJJBAWZRGZ-HNNXBMFYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50319838 ((S)-4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Canada Ltd Curated by ChEMBL | Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Bioorg Med Chem Lett 20: 3760-3 (2010) Article DOI: 10.1016/j.bmcl.2010.04.065 BindingDB Entry DOI: 10.7270/Q20P106K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostanoid DP receptor (Homo sapiens (Human)) | BDBM50319838 ((S)-4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 209 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Canada Ltd Curated by ChEMBL | Assay Description Displacement of [3H]PGD2 from human Prostanoid DP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting | Bioorg Med Chem Lett 20: 3760-3 (2010) Article DOI: 10.1016/j.bmcl.2010.04.065 BindingDB Entry DOI: 10.7270/Q20P106K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human)) | BDBM50319838 ((S)-4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Canada Ltd Curated by ChEMBL | Assay Description Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat... | Bioorg Med Chem Lett 20: 3760-3 (2010) Article DOI: 10.1016/j.bmcl.2010.04.065 BindingDB Entry DOI: 10.7270/Q20P106K | |||||||||||
More data for this Ligand-Target Pair |