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SMILES: CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1cccc(Cl)c1

InChI Key: InChIKey=DBRAEKJTQXKQQT-VCUSLETLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50320004   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50320004
PNG
((2R)-1-(1-(3-chlorophenyl)ethoxy)-3-(2-methyl-1-(n...)
Show SMILES CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C25H30ClNO2/c1-18(21-9-6-10-23(26)14-21)29-17-24(28)16-27-25(2,3)15-19-11-12-20-7-4-5-8-22(20)13-19/h4-14,18,24,27-28H,15-17H2,1-3H3/t18?,24-/m1/s1
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n/an/a 220n/an/an/an/an/an/a



Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assay

Bioorg Med Chem Lett 20: 3809-13 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.035
BindingDB Entry DOI: 10.7270/Q2765FGD
More data for this
Ligand-Target Pair