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SMILES: CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1C

InChI Key: InChIKey=RMVIYQIZWZQWDI-PIFIWZBESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50320005   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50320005
PNG
((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Show SMILES CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1C |r|
Show InChI InChI=1S/C26H33NO2/c1-19-9-5-8-12-25(19)20(2)29-18-24(28)17-27-26(3,4)16-21-13-14-22-10-6-7-11-23(22)15-21/h5-15,20,24,27-28H,16-18H2,1-4H3/t20?,24-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assay

Bioorg Med Chem Lett 20: 3809-13 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.035
BindingDB Entry DOI: 10.7270/Q2765FGD
More data for this
Ligand-Target Pair