BDBM50321611 7-((6-chloropyridin-3-yl)methoxy)-2-(4-((6-chloropyridin-3-yl)methoxy)phenyl)-4H-chromen-4-one::CHEMBL1169925
SMILES: Clc1ccc(COc2ccc(cc2)-c2cc(=O)c3ccc(OCc4ccc(Cl)nc4)cc3o2)cn1
InChI Key: InChIKey=ACEACBDHWOKIAR-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50321611 (7-((6-chloropyridin-3-yl)methoxy)-2-(4-((6-chlorop...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Punjabi University Curated by ChEMBL | Assay Description Inhibition of telomerase activity (unknown origin) | Eur J Med Chem 84: 206-39 (2014) Article DOI: 10.1016/j.ejmech.2014.07.013 BindingDB Entry DOI: 10.7270/Q2GH9KMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50321611 (7-((6-chloropyridin-3-yl)methoxy)-2-(4-((6-chlorop...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of human telomerase in human SGC7901 cells by TRAP assay | Bioorg Med Chem Lett 20: 4163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.05.080 BindingDB Entry DOI: 10.7270/Q28G8MPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase I, thermostable (Thermus aquaticus) | BDBM50321611 (7-((6-chloropyridin-3-yl)methoxy)-2-(4-((6-chlorop...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of Thermus aquaticus taq polymerase | Bioorg Med Chem Lett 20: 4163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.05.080 BindingDB Entry DOI: 10.7270/Q28G8MPC | |||||||||||
More data for this Ligand-Target Pair |