BDBM50322981 CHEMBL1210207::N-(1-((2,6-diethoxy-4'-fluorobiphenyl-4-yl)methyl)piperidin-4-yl)-5-methylnicotinamide
SMILES: CCOc1cc(CN2CCC(CC2)NC(=O)c2cncc(C)c2)cc(OCC)c1-c1ccc(F)cc1
InChI Key: InChIKey=XQGOSGUJZCQEOJ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50322981 (CHEMBL1210207 | N-(1-((2,6-diethoxy-4'-fluorobiphe...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of radio labeled 11 Tyr SST14 from human SST5 receptor expressed in CHO cells | Bioorg Med Chem Lett 20: 4521-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.026 BindingDB Entry DOI: 10.7270/Q2J103BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50322981 (CHEMBL1210207 | N-(1-((2,6-diethoxy-4'-fluorobiphe...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of MK-499 binding to human ERG | ACS Med Chem Lett 9: 1082-1087 (2018) Article DOI: 10.1021/acsmedchemlett.8b00305 BindingDB Entry DOI: 10.7270/Q2ZP48TS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50322981 (CHEMBL1210207 | N-(1-((2,6-diethoxy-4'-fluorobiphe...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Displacement of (3-125I-Tyr11)-SRIF-28 from human SSTR5 expressed in CHO-K1 cell membranes by filtration binding assay | ACS Med Chem Lett 9: 1082-1087 (2018) Article DOI: 10.1021/acsmedchemlett.8b00305 BindingDB Entry DOI: 10.7270/Q2ZP48TS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50322981 (CHEMBL1210207 | N-(1-((2,6-diethoxy-4'-fluorobiphe...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Antagonist activity at human SSTR5 expressed in CHO-K1 cell membranes assessed as reduction in SST-28-induced inhibition of forskolin-stimulated cAMP... | ACS Med Chem Lett 9: 1082-1087 (2018) Article DOI: 10.1021/acsmedchemlett.8b00305 BindingDB Entry DOI: 10.7270/Q2ZP48TS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor (Mus musculus) | BDBM50322981 (CHEMBL1210207 | N-(1-((2,6-diethoxy-4'-fluorobiphe...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Antagonist activity at mouse SSTR5 expressed in CHO-K1 cell membranes assessed as reduction in SST-28-induced inhibition of forskolin-stimulated cAMP... | ACS Med Chem Lett 9: 1082-1087 (2018) Article DOI: 10.1021/acsmedchemlett.8b00305 BindingDB Entry DOI: 10.7270/Q2ZP48TS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM50322981 (CHEMBL1210207 | N-(1-((2,6-diethoxy-4'-fluorobiphe...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Antagonist activity at human SSTR1 expressed in CHO-K1 cell membranes | ACS Med Chem Lett 9: 1082-1087 (2018) Article DOI: 10.1021/acsmedchemlett.8b00305 BindingDB Entry DOI: 10.7270/Q2ZP48TS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM50322981 (CHEMBL1210207 | N-(1-((2,6-diethoxy-4'-fluorobiphe...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Antagonist activity at human SST5 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by FRET assay | Bioorg Med Chem Lett 20: 4521-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.026 BindingDB Entry DOI: 10.7270/Q2J103BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor (Mus musculus) | BDBM50322981 (CHEMBL1210207 | N-(1-((2,6-diethoxy-4'-fluorobiphe...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Displacement of (3-125I-Tyr11)-SRIF-28 from mouse SSTR5 expressed in CHO-K1 cell membranes by filtration binding assay | ACS Med Chem Lett 9: 1082-1087 (2018) Article DOI: 10.1021/acsmedchemlett.8b00305 BindingDB Entry DOI: 10.7270/Q2ZP48TS | |||||||||||
More data for this Ligand-Target Pair |