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BDBM50323818 6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-(1-methylpiperidin-4-yloxy)quinazoline::CHEMBL1214629

SMILES: COc1cc2nc(nc(OC3CCN(C)CC3)c2cc1OC)N1CCCN(C)CC1

InChI Key: InChIKey=SIGXDIUFWPPFGH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50323818   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein G9a (G9a)


(Homo sapiens (Human))		BDBM50323818
PNG
(6,7-Dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-(1-...)
Show SMILES COc1cc2nc(nc(OC3CCN(C)CC3)c2cc1OC)N1CCCN(C)CC1
Show InChI InChI=1S/C22H33N5O3/c1-25-8-5-9-27(13-12-25)22-23-18-15-20(29-4)19(28-3)14-17(18)21(24-22)30-16-6-10-26(2)11-7-16/h14-16H,5-13H2,1-4H3
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+7n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of methyl transferase activity of G9a assessed as inhibition of H3K9 methylation by chemiluminescence based oxygen tunneling assay

J Med Chem 53: 5844-57 (2010)


Article DOI: 10.1021/jm100478y
BindingDB Entry DOI: 10.7270/Q2DZ08H1
More data for this
Ligand-Target Pair