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SMILES: Cc1nc(cs1)C#CC1=C\C(CCC1)=N\OCCOCCF

InChI Key: InChIKey=ZNBQWYPIVCZQIR-XDJHFCHBSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50323926   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50323926
PNG
((E)-3-((2-Methylthiazol-4-yl)ethynyl)cyclohex-2-en...)
Show SMILES Cc1nc(cs1)C#CC1=C\C(CCC1)=N\OCCOCCF |t:9|
Show InChI InChI=1S/C16H19FN2O2S/c1-13-18-16(12-22-13)6-5-14-3-2-4-15(11-14)19-21-10-9-20-8-7-17/h11-12H,2-4,7-10H2,1H3/b19-15+
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Article
PubMed
 21.9n/an/an/an/an/an/an/an/a



ETH Zurich (Swiss Federal Institute of Technology)

Curated by ChEMBL


Assay Description
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation counting

Bioorg Med Chem 18: 6044-54 (2010)


Article DOI: 10.1016/j.bmc.2010.06.070
BindingDB Entry DOI: 10.7270/Q2862GMS
More data for this
Ligand-Target Pair