BDBM50324276 (Z)-N-[2-Oxo-3-({4-oxo-3-[3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-5-yl]benzenesulfonamide::CHEMBL1215284

SMILES: O=C1Nc2ccc(NS(=O)(=O)c3ccccc3)cc2C1=Cc1[nH]c2CCCC(=O)c2c1CCCN1CCCC1

InChI Key: InChIKey=GFDMYTNCMHUIAT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50324276   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50324276 ((Z)-N-[2-Oxo-3-({4-oxo-3-[3-(pyrrolidin-1-yl)propy...) Show SMILES O=C1Nc2ccc(NS(=O)(=O)c3ccccc3)cc2C1=Cc1[nH]c2CCCC(=O)c2c1CCCN1CCCC1 |w:20.23| Show InChI InChI=1S/C30H32N4O4S/c35-28-12-6-11-26-29(28)22(10-7-17-34-15-4-5-16-34)27(31-26)19-24-23-18-20(13-14-25(23)32-30(24)36)33-39(37,38)21-8-2-1-3-9-21/h1-3,8-9,13-14,18-19,31,33H,4-7,10-12,15-17H2,(H,32,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Development Center for Biotechnology Curated by ChEMBL					Assay Description Inhibition of recombinant aurora A				J Med Chem 53: 5929-41 (2010) Article DOI: 10.1021/jm1001869 BindingDB Entry DOI: 10.7270/Q2XS5VKS
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50324276 ((Z)-N-[2-Oxo-3-({4-oxo-3-[3-(pyrrolidin-1-yl)propy...) Show SMILES O=C1Nc2ccc(NS(=O)(=O)c3ccccc3)cc2C1=Cc1[nH]c2CCCC(=O)c2c1CCCN1CCCC1 |w:20.23| Show InChI InChI=1S/C30H32N4O4S/c35-28-12-6-11-26-29(28)22(10-7-17-34-15-4-5-16-34)27(31-26)19-24-23-18-20(13-14-25(23)32-30(24)36)33-39(37,38)21-8-2-1-3-9-21/h1-3,8-9,13-14,18-19,31,33H,4-7,10-12,15-17H2,(H,32,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Development Center for Biotechnology Curated by ChEMBL					Assay Description Inhibition of recombinant aurora B				J Med Chem 53: 5929-41 (2010) Article DOI: 10.1021/jm1001869 BindingDB Entry DOI: 10.7270/Q2XS5VKS
					More data for this Ligand-Target Pair