BDBM50324509 CHEMBL1215373::N-(2-(1H-imidazol-4-yl)ethyl)-6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamide

SMILES: Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)NCCc1cnc[nH]1

InChI Key: InChIKey=BXRCSZPNYWMUNQ-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50324509   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50324509 (CHEMBL1215373 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(a...) Show SMILES Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)NCCc1cnc[nH]1 |(10.76,-1,;9.45,-1.81,;8.1,-1.09,;6.8,-1.9,;5.33,-1.46,;4.46,-2.74,;5.4,-3.96,;6.85,-3.44,;8.2,-4.17,;9.51,-3.36,;10.87,-4.08,;12.17,-3.27,;8.17,-5.7,;6.82,-6.44,;6.79,-7.98,;8.11,-8.78,;8.08,-10.32,;9.46,-8.02,;9.48,-6.48,;10.83,-5.74,;2.92,-2.78,;2.11,-1.48,;2.19,-4.14,;.65,-4.18,;-.08,-5.54,;-1.62,-5.59,;-2.57,-4.37,;-4.01,-4.88,;-3.96,-6.42,;-2.49,-6.86,)| Show InChI InChI=1S/C20H19Cl2N7O/c1-11-15(7-23)18(14-3-2-12(21)6-16(14)22)29-9-17(28-20(29)27-11)19(30)25-5-4-13-8-24-10-26-13/h2-3,6,8-10H,4-5,7,23H2,1H3,(H,24,26)(H,25,30)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of human DPP8				J Med Chem 53: 5620-8 (2010) Article DOI: 10.1021/jm100634a BindingDB Entry DOI: 10.7270/Q2S182PX
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50324509 (CHEMBL1215373 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(a...) Show SMILES Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)NCCc1cnc[nH]1 |(10.76,-1,;9.45,-1.81,;8.1,-1.09,;6.8,-1.9,;5.33,-1.46,;4.46,-2.74,;5.4,-3.96,;6.85,-3.44,;8.2,-4.17,;9.51,-3.36,;10.87,-4.08,;12.17,-3.27,;8.17,-5.7,;6.82,-6.44,;6.79,-7.98,;8.11,-8.78,;8.08,-10.32,;9.46,-8.02,;9.48,-6.48,;10.83,-5.74,;2.92,-2.78,;2.11,-1.48,;2.19,-4.14,;.65,-4.18,;-.08,-5.54,;-1.62,-5.59,;-2.57,-4.37,;-4.01,-4.88,;-3.96,-6.42,;-2.49,-6.86,)| Show InChI InChI=1S/C20H19Cl2N7O/c1-11-15(7-23)18(14-3-2-12(21)6-16(14)22)29-9-17(28-20(29)27-11)19(30)25-5-4-13-8-24-10-26-13/h2-3,6,8-10H,4-5,7,23H2,1H3,(H,24,26)(H,25,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of human DPP9				J Med Chem 53: 5620-8 (2010) Article DOI: 10.1021/jm100634a BindingDB Entry DOI: 10.7270/Q2S182PX
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50324509 (CHEMBL1215373 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(a...) Show SMILES Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)NCCc1cnc[nH]1 |(10.76,-1,;9.45,-1.81,;8.1,-1.09,;6.8,-1.9,;5.33,-1.46,;4.46,-2.74,;5.4,-3.96,;6.85,-3.44,;8.2,-4.17,;9.51,-3.36,;10.87,-4.08,;12.17,-3.27,;8.17,-5.7,;6.82,-6.44,;6.79,-7.98,;8.11,-8.78,;8.08,-10.32,;9.46,-8.02,;9.48,-6.48,;10.83,-5.74,;2.92,-2.78,;2.11,-1.48,;2.19,-4.14,;.65,-4.18,;-.08,-5.54,;-1.62,-5.59,;-2.57,-4.37,;-4.01,-4.88,;-3.96,-6.42,;-2.49,-6.86,)| Show InChI InChI=1S/C20H19Cl2N7O/c1-11-15(7-23)18(14-3-2-12(21)6-16(14)22)29-9-17(28-20(29)27-11)19(30)25-5-4-13-8-24-10-26-13/h2-3,6,8-10H,4-5,7,23H2,1H3,(H,24,26)(H,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP4 assessed as Gly-Pro-pNA cleavage				J Med Chem 53: 5620-8 (2010) Article DOI: 10.1021/jm100634a BindingDB Entry DOI: 10.7270/Q2S182PX
					More data for this Ligand-Target Pair