BDBM50324583 (R)-N-(2-(2-(Dimethylamino)ethoxy)-3-fluoro-4-(1H-pyrazol-4-yl)phenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::CHEMBL1215453

SMILES: COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(-c2cn[nH]c2)c(F)c1OCCN(C)C

InChI Key: InChIKey=SCVXFTRWQZQRMC-OAQYLSRUSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50324583   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324583 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-3-fluoro-4-(1H-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(-c2cn[nH]c2)c(F)c1OCCN(C)C |r| Show InChI InChI=1S/C24H28FN5O3/c1-30(2)8-9-33-23-20(7-6-19(22(23)25)17-13-27-28-14-17)29-24(31)21-11-16-10-18(32-3)5-4-15(16)12-26-21/h4-7,10,13-14,21,26H,8-9,11-12H2,1-3H3,(H,27,28)(H,29,31)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324583 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-3-fluoro-4-(1H-...) Show SMILES COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(-c2cn[nH]c2)c(F)c1OCCN(C)C |r| Show InChI InChI=1S/C24H28FN5O3/c1-30(2)8-9-33-23-20(7-6-19(22(23)25)17-13-27-28-14-17)29-24(31)21-11-16-10-18(32-3)5-4-15(16)12-26-21/h4-7,10,13-14,21,26H,8-9,11-12H2,1-3H3,(H,27,28)(H,29,31)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair