BDBM50324591 (R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)-phenyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxamide::CHEMBL1212964

SMILES: COc1ccc2C[C@@H](NCc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1

InChI Key: InChIKey=PCTPVZRMOUJRQY-JOCHJYFZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50324591   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324591 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4...) Show SMILES COc1ccc2C[C@@H](NCc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H29N5O3/c1-29(2)8-9-32-23-12-17(19-14-26-27-15-19)5-7-21(23)28-24(30)22-11-16-4-6-20(31-3)10-18(16)13-25-22/h4-7,10,12,14-15,22,25H,8-9,11,13H2,1-3H3,(H,26,27)(H,28,30)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
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