BDBM50324600 CHEMBL1215238::rac-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-ethoxy-1,2,3,4-tetrahydroiso-quinoline-3-carboxamide

SMILES: CCOc1ccc2CNC(Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1

InChI Key: InChIKey=JAPRDKNCYQPDDQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50324600   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324600 (CHEMBL1215238 | rac-N-(2-(2-(Dimethylamino)ethoxy)...) Show SMILES CCOc1ccc2CNC(Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 Show InChI InChI=1S/C25H31N5O3/c1-4-32-21-7-5-18-14-26-23(12-19(18)11-21)25(31)29-22-8-6-17(20-15-27-28-16-20)13-24(22)33-10-9-30(2)3/h5-8,11,13,15-16,23,26H,4,9-10,12,14H2,1-3H3,(H,27,28)(H,29,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
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