BDBM50324603 (R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-pyrazol-4-yl)phenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::CHEMBL1215525

SMILES: CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1C

InChI Key: InChIKey=DQDGPBWHPGDZRS-JOCHJYFZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50324603   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324603 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1C |r| Show InChI InChI=1S/C24H28FN5O2/c1-29(2)8-9-32-23-11-19(18-13-26-27-14-18)20(25)12-21(23)28-24(31)22-10-16-6-4-5-7-17(16)15-30(22)3/h4-7,11-14,22H,8-10,15H2,1-3H3,(H,26,27)(H,28,31)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50324603 ((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...) Show SMILES CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1C |r| Show InChI InChI=1S/C24H28FN5O2/c1-29(2)8-9-32-23-11-19(18-13-26-27-14-18)20(25)12-21(23)28-24(31)22-10-16-6-4-5-7-17(16)15-30(22)3/h4-7,11-14,22H,8-10,15H2,1-3H3,(H,26,27)(H,28,31)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK2				J Med Chem 53: 5727-37 (2010) Article DOI: 10.1021/jm100579r BindingDB Entry DOI: 10.7270/Q2833S8C
					More data for this Ligand-Target Pair