BDBM50324896 6-[N-Ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)amino]nicotinic acid::CHEMBL1221641
SMILES: CCN(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(cn1)C(O)=O
InChI Key: InChIKey=RXCTZCYFGJAJCU-UHFFFAOYSA-N
Data: 4 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50324896 (6-[N-Ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.28 | n/a | n/a | n/a | n/a |
Okayama University Curated by ChEMBL | Assay Description Agonist activity at RXRalpha by luciferase reporter gene assay | Bioorg Med Chem Lett 20: 5139-42 (2010) Article DOI: 10.1016/j.bmcl.2010.07.012 BindingDB Entry DOI: 10.7270/Q20G3KB3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor (Homo sapiens (Human)) | BDBM50324896 (6-[N-Ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Arizona State University Curated by ChEMBL | Assay Description Agonist activity at human RXR binding domain and activation domain expressed in human HCT116 cells assessed as rexinoid activity incubated for 24 hrs... | J Med Chem 59: 8924-8940 (2016) Article DOI: 10.1021/acs.jmedchem.6b00812 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50324896 (6-[N-Ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a |
Okayama University Graduate School of Medicine Curated by ChEMBL | Assay Description Partial agonist activity at RXRalpha (unknown origin) expressed in COS1 cells after 18 hrs by luciferase reporter gene assay | J Med Chem 56: 1865-77 (2013) Article DOI: 10.1021/jm400033f BindingDB Entry DOI: 10.7270/Q2348MR8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50324896 (6-[N-Ethyl(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at RXRalpha transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assay | ACS Med Chem Lett 1: 521-525 (2010) Article DOI: 10.1021/ml100184k BindingDB Entry DOI: 10.7270/Q28S4Q6X | |||||||||||
More data for this Ligand-Target Pair |