BDBM50325735 (R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-yl)methyl)-1-phenylethanamine::CHEMBL1224341
SMILES: COc1ccc(CN[C@H](C)c2ccccc2)cc1-c1ccc(cc1)C(F)(F)F
InChI Key: InChIKey=JRFWKLXVTAAZAB-MRXNPFEDSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium-sensing receptor (CaSR) (Homo sapiens (Human)) | BDBM50325735 ((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...) | PDB GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calcium | Bioorg Med Chem Lett 20: 5544-7 (2010) Article DOI: 10.1016/j.bmcl.2010.07.060 BindingDB Entry DOI: 10.7270/Q2Z89CM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium-sensing receptor (CaSR) (Homo sapiens (Human)) | BDBM50325735 ((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...) | PDB GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calcium | Bioorg Med Chem Lett 20: 5544-7 (2010) Article DOI: 10.1016/j.bmcl.2010.07.060 BindingDB Entry DOI: 10.7270/Q2Z89CM3 | |||||||||||
More data for this Ligand-Target Pair |