BindingDB PrimarySearch

BDBM50325822 CHEMBL1224527::trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol

SMILES: Oc1ccc2[C@@H]3CNCC[C@H]3[C@@H](Cc2c1O)c1ccccc1

InChI Key: InChIKey=FKYWSGYMKJUZEP-ZOBUZTSGSA-N

Data: 15 KI 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50325822
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	47	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 6366-74 (2012) Article DOI: 10.1016/j.bmc.2012.08.058 BindingDB Entry DOI: 10.7270/Q2G161X3
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 6366-74 (2012) Article DOI: 10.1016/j.bmc.2012.08.058 BindingDB Entry DOI: 10.7270/Q2G161X3
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Displacement of [3H]-N-methylspiperone from human dopamine D2long receptor expressed in HEK293 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 6366-74 (2012) Article DOI: 10.1016/j.bmc.2012.08.058 BindingDB Entry DOI: 10.7270/Q2G161X3
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to adrenergic Alpha-2C receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(1B) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to dopamine D5 receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to adrenergic alpha2A receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2B adrenergic receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to adrenergic alpha2B receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to dopamine D1 receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to dopamine D3 receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to 5HT7 receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.40E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to adrenergic alpha1A receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.50E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to dopamine D2 receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to adrenergic kappa opioid receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to 5HT3 receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.65E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Binding affinity to dopamine D4 receptor				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50325822 (CHEMBL1224527 \| trans-(5R)-5-phenyl-1,2,3,4,4a,5,6...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.640	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Agonist activity at human D1 receptor assessed as cAMP accumulation				Bioorg Med Chem 18: 6763-70 (2010) Article DOI: 10.1016/j.bmc.2010.07.052 BindingDB Entry DOI: 10.7270/Q29K4BFR
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair