BDBM50325875 CHEMBL1224286::endo-3-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)-N-methylbenzamide

SMILES: CNC(=O)c1cccc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)c1

InChI Key: InChIKey=ANRXIHXQFLKMRJ-KXTWHKPSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325875   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50325875 (CHEMBL1224286 | endo-3-((1R,5S)-8-benzyl-8-azabicy...) Show SMILES CNC(=O)c1cccc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)c1 |r,TLB:18:17:16.10.11:14.13| Show InChI InChI=1S/C22H26N2O2/c1-23-22(25)17-8-5-9-20(12-17)26-21-13-18-10-11-19(14-21)24(18)15-16-6-3-2-4-7-16/h2-9,12,18-19,21H,10-11,13-15H2,1H3,(H,23,25)/t18-,19+,21+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human kappa opioid receptor expressed in HEK cells assessed as inhibition of dynorphin A-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5405-10 (2010) Article DOI: 10.1016/j.bmcl.2010.07.112 BindingDB Entry DOI: 10.7270/Q2X92BHQ
					More data for this Ligand-Target Pair