BDBM50325876 CHEMBL1224287::endo-3-((1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yloxy)-N,N-dimethylbenzamide

SMILES: CN(C)C(=O)c1cccc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)c1

InChI Key: InChIKey=CADFLVYCUAUFSZ-XVAYZXCPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325876   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50325876 (CHEMBL1224287 | endo-3-((1R,5S)-8-benzyl-8-azabicy...) Show SMILES CN(C)C(=O)c1cccc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccccc2)c1 |r,TLB:19:18:17.11.12:15.14| Show InChI InChI=1S/C23H28N2O2/c1-24(2)23(26)18-9-6-10-21(13-18)27-22-14-19-11-12-20(15-22)25(19)16-17-7-4-3-5-8-17/h3-10,13,19-20,22H,11-12,14-16H2,1-2H3/t19-,20+,22+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human kappa opioid receptor expressed in HEK cells assessed as inhibition of dynorphin A-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 20: 5405-10 (2010) Article DOI: 10.1016/j.bmcl.2010.07.112 BindingDB Entry DOI: 10.7270/Q2X92BHQ
					More data for this Ligand-Target Pair