BDBM50325899 2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one::CHEMBL1223819

SMILES: FC(F)(F)c1nc2ncccc2c(=O)[nH]1

InChI Key: InChIKey=RNYZPQSAGWZVGM-UHFFFAOYSA-N

Data: 3 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50325899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hydroxycarboxylic acid receptor 2 (Rattus norvegicus)	BDBM50325899 (2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...) Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1 Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at rat GPR109A receptor assessed as GTPgammaS binding				Bioorg Med Chem Lett 20: 5426-30 (2010) Article DOI: 10.1016/j.bmcl.2010.07.108 BindingDB Entry DOI: 10.7270/Q2NV9JGF
					More data for this Ligand-Target Pair
HM74 nicotinic acid GPCR (Homo sapiens (Human))	BDBM50325899 (2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...) Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1 Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of radioligand from human GPR109B				Bioorg Med Chem Lett 20: 5426-30 (2010) Article DOI: 10.1016/j.bmcl.2010.07.108 BindingDB Entry DOI: 10.7270/Q2NV9JGF
					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Rattus norvegicus)	BDBM50325899 (2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...) Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1 Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of radioligand from rat GPR109A				Bioorg Med Chem Lett 20: 5426-30 (2010) Article DOI: 10.1016/j.bmcl.2010.07.108 BindingDB Entry DOI: 10.7270/Q2NV9JGF
					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50325899 (2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...) Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1 Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Agonist activity at human GPR109A receptor assessed as GTPgammaS binding				Bioorg Med Chem Lett 20: 5426-30 (2010) Article DOI: 10.1016/j.bmcl.2010.07.108 BindingDB Entry DOI: 10.7270/Q2NV9JGF
					More data for this Ligand-Target Pair
Hydroxycarboxylic acid receptor 2 (Homo sapiens (Human))	BDBM50325899 (2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...) Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1 Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of radioligand from human GPR109A				Bioorg Med Chem Lett 20: 5426-30 (2010) Article DOI: 10.1016/j.bmcl.2010.07.108 BindingDB Entry DOI: 10.7270/Q2NV9JGF
					More data for this Ligand-Target Pair