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BDBM50325899 2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one::CHEMBL1223819

SMILES: FC(F)(F)c1nc2ncccc2c(=O)[nH]1

InChI Key: InChIKey=RNYZPQSAGWZVGM-UHFFFAOYSA-N

Data: 3 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50325899   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hydroxycarboxylic acid receptor 2


(Rattus norvegicus)
BDBM50325899
PNG
(2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...)
Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1
Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 60n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR109A receptor assessed as GTPgammaS binding


Bioorg Med Chem Lett 20: 5426-30 (2010)

More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50325899
PNG
(2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...)
Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1
Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)
KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Displacement of radioligand from human GPR109B


Bioorg Med Chem Lett 20: 5426-30 (2010)

More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Rattus norvegicus)
BDBM50325899
PNG
(2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...)
Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1
Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 400n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Displacement of radioligand from rat GPR109A


Bioorg Med Chem Lett 20: 5426-30 (2010)

More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (human))
BDBM50325899
PNG
(2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...)
Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1
Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.70E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109A receptor assessed as GTPgammaS binding


Bioorg Med Chem Lett 20: 5426-30 (2010)

More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (human))
BDBM50325899
PNG
(2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-on...)
Show SMILES FC(F)(F)c1nc2ncccc2c(=O)[nH]1
Show InChI InChI=1S/C8H4F3N3O/c9-8(10,11)7-13-5-4(6(15)14-7)2-1-3-12-5/h1-3H,(H,12,13,14,15)
Reactome pathway
KEGG

UniProtKB/SwissProt

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antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Displacement of radioligand from human GPR109A


Bioorg Med Chem Lett 20: 5426-30 (2010)

More data for this
Ligand-Target Pair