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BDBM50326184 (E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-one O-2-(piperdin-1-yl)ethyl Oxime::CHEMBL1243165

SMILES: COc1ccc-2c(c1)\C(=N/OCCN1CCCCC1)c1c-2cnc2ccccc12

InChI Key: InChIKey=XNYOXLFGJXQVPI-SHHOIMCASA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326184   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA topoisomerase I (Topo I)


(Homo sapiens (Human))
BDBM50326184
PNG
((E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-one O-2...)
Show SMILES COc1ccc-2c(c1)\C(=N/OCCN1CCCCC1)c1c-2cnc2ccccc12
Show InChI InChI=1S/C24H25N3O2/c1-28-17-9-10-18-20(15-17)24(26-29-14-13-27-11-5-2-6-12-27)23-19-7-3-4-8-22(19)25-16-21(18)23/h3-4,7-10,15-16H,2,5-6,11-14H2,1H3/b26-24+
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.65E+4n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis


J Med Chem 53: 6164-79 (2010)


Article DOI: 10.1021/jm1005447
BindingDB Entry DOI: 10.7270/Q2BZ6710
More data for this
Ligand-Target Pair