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BDBM50326189 (E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-11-one O-2-(Piperidin-1-yl)ethyl Oxime::CHEMBL1243230

SMILES: COc1ccc-2c(c1)\C(=N/OCCN1CCCCC1)c1c-2c(=O)[nH]c2ccccc12

InChI Key: InChIKey=VFTKFZSHUCTNDS-WNAAXNPUSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326189   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA topoisomerase I (Topo I)


(Homo sapiens (Human))
BDBM50326189
PNG
((E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-...)
Show SMILES COc1ccc-2c(c1)\C(=N/OCCN1CCCCC1)c1c-2c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C24H25N3O3/c1-29-16-9-10-17-19(15-16)23(26-30-14-13-27-11-5-2-6-12-27)21-18-7-3-4-8-20(18)25-24(28)22(17)21/h3-4,7-10,15H,2,5-6,11-14H2,1H3,(H,25,28)/b26-23+
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis


J Med Chem 53: 6164-79 (2010)


Article DOI: 10.1021/jm1005447
BindingDB Entry DOI: 10.7270/Q2BZ6710
More data for this
Ligand-Target Pair