BDBM50326194 (E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one O-2-(piperidin-1-yl)ethyl oxime::9-Methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one O-2-(piperidin-1-yl)ethyl oxime::CHEMBL407157

SMILES: COc1ccc-2c(c1)\C(=N/OCCN1CCCCC1)c1c-2c(nc2ccccc12)N1CCNCC1

InChI Key: InChIKey=XBOLAXKZIMALDV-TVKQRKNISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326194   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase I (Topo I) (Homo sapiens (Human))	BDBM50326194 ((E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]...) Show SMILES COc1ccc-2c(c1)\C(=N/OCCN1CCCCC1)c1c-2c(nc2ccccc12)N1CCNCC1 Show InChI InChI=1S/C28H33N5O2/c1-34-20-9-10-21-23(19-20)27(31-35-18-17-32-13-5-2-6-14-32)25-22-7-3-4-8-24(22)30-28(26(21)25)33-15-11-29-12-16-33/h3-4,7-10,19,29H,2,5-6,11-18H2,1H3/b31-27+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kaohsiung Medical University Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis				J Med Chem 53: 6164-79 (2010) Article DOI: 10.1021/jm1005447 BindingDB Entry DOI: 10.7270/Q2BZ6710
					More data for this Ligand-Target Pair