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BDBM50326194 (E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one O-2-(piperidin-1-yl)ethyl oxime::9-Methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one O-2-(piperidin-1-yl)ethyl oxime::CHEMBL407157

SMILES: COc1ccc-2c(c1)\C(=N/OCCN1CCCCC1)c1c-2c(nc2ccccc12)N1CCNCC1

InChI Key: InChIKey=XBOLAXKZIMALDV-TVKQRKNISA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326194   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA topoisomerase I (Topo I)


(Homo sapiens (Human))
BDBM50326194
PNG
((E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]...)
Show SMILES COc1ccc-2c(c1)\C(=N/OCCN1CCCCC1)c1c-2c(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C28H33N5O2/c1-34-20-9-10-21-23(19-20)27(31-35-18-17-32-13-5-2-6-14-32)25-22-7-3-4-8-24(22)30-28(26(21)25)33-15-11-29-12-16-33/h3-4,7-10,19,29H,2,5-6,11-18H2,1H3/b31-27+
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.15E+4n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis


J Med Chem 53: 6164-79 (2010)


Article DOI: 10.1021/jm1005447
BindingDB Entry DOI: 10.7270/Q2BZ6710
More data for this
Ligand-Target Pair