BDBM50326195 (E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one O-2-morpholinoethyl oxime::CHEMBL1243355

SMILES: COc1ccc-2c(c1)\C(=N/OCCN1CCOCC1)c1c-2c(nc2ccccc12)N1CCNCC1

InChI Key: InChIKey=MTNOUBCHLQPGQW-URGPHPNLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326195   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase I (Topo I) (Homo sapiens (Human))	BDBM50326195 ((E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]...) Show SMILES COc1ccc-2c(c1)\C(=N/OCCN1CCOCC1)c1c-2c(nc2ccccc12)N1CCNCC1 Show InChI InChI=1S/C27H31N5O3/c1-33-19-6-7-20-22(18-19)26(30-35-17-14-31-12-15-34-16-13-31)24-21-4-2-3-5-23(21)29-27(25(20)24)32-10-8-28-9-11-32/h2-7,18,28H,8-17H2,1H3/b30-26+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kaohsiung Medical University Curated by ChEMBL					Assay Description Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis				J Med Chem 53: 6164-79 (2010) Article DOI: 10.1021/jm1005447 BindingDB Entry DOI: 10.7270/Q2BZ6710
					More data for this Ligand-Target Pair