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BDBM50326196 (E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-11-one O-2-(pyrrolidin-1-yl)ethyl Oxime::CHEMBL1243229

SMILES: COc1ccc-2c(c1)\C(=N/OCCN1CCCC1)c1c-2c(=O)[nH]c2ccccc12

InChI Key: InChIKey=JDWSZTDCKCPHIR-YYDJUVGSSA-N

Data: 1 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326196   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA topoisomerase I (Topo I)


(Homo sapiens (Human))
BDBM50326196
PNG
((E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-...)
Show SMILES COc1ccc-2c(c1)\C(=N/OCCN1CCCC1)c1c-2c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C23H23N3O3/c1-28-15-8-9-16-18(14-15)22(25-29-13-12-26-10-4-5-11-26)20-17-6-2-3-7-19(17)24-23(27)21(16)20/h2-3,6-9,14H,4-5,10-13H2,1H3,(H,24,27)/b25-22+
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.76E+3n/an/an/an/an/an/a



Kaohsiung Medical University

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresis


J Med Chem 53: 6164-79 (2010)


Article DOI: 10.1021/jm1005447
BindingDB Entry DOI: 10.7270/Q2BZ6710
More data for this
Ligand-Target Pair