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BDBM50326229 CHEMBL1242924::N-{1-[3-(6,7-Difluoro-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-propyl]-piperidin-4-yl}-acetamide

SMILES: CC(=O)NC1CCN(CCCN2C(=O)CCc3cc(F)c(F)cc23)CC1

InChI Key: InChIKey=YIFIPJKYDULCSS-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50326229   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50326229
PNG
(CHEMBL1242924 | N-{1-[3-(6,7-Difluoro-2-oxo-3,4-di...)
Show SMILES CC(=O)NC1CCN(CCCN2C(=O)CCc3cc(F)c(F)cc23)CC1
Show InChI InChI=1S/C19H25F2N3O2/c1-13(25)22-15-5-9-23(10-6-15)7-2-8-24-18-12-17(21)16(20)11-14(18)3-4-19(24)26/h11-12,15H,2-10H2,1H3,(H,22,25)
UniProtKB/SwissProt
UniProtKB/TrEMBL

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Article
PubMed
n/an/an/an/a 86n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay

J Med Chem 53: 6386-97 (2010)


Article DOI: 10.1021/jm100697g
BindingDB Entry DOI: 10.7270/Q2765G9K
More data for this
Ligand-Target Pair